Position of alternatives: insulin sensitizers and others
نویسندگان
چکیده
منابع مشابه
Modulation of insulin signalling by insulin sensitizers.
Insulin resistance is a hallmark of Type II diabetes. It is well documented that insulin sensitizers such as peroxisome-proliferator-activated receptor gamma agonists and aspirin improve insulin action in vivo. The detailed mechanisms by which the insulin sensitizers promote insulin signalling, however, are not completely understood and remain somewhat controversial. In the present review, we s...
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Insulin resistance is the undisputed root cause of type 2 diabetes mellitus (T2DM). There is currently an unmet demand for safe and effective insulin sensitizers, owing to the restricted prescription or removal from market of certain approved insulin sensitizers, such as thiazolidinediones (TZDs), because of safety concerns. Effective insulin sensitizers without TZD-like side effects will there...
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A number of fascinating reports discussed treatment with metformin. Jones and colleagues studied 82 children with type 2 diabetes aged 10 to 16 years who had an average HbA1c of 8.6%, fasting glucose of 182 mg/dL, and weighing 92 kg. Results of this study showed that metformin at a dose of 500-1000 mg twice daily lowered fasting glucose levels by 43 mg/dL in 40 patients. Patients in the control...
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Preclinical, early phase clinical trials and epidemiological evidence support the potential role of insulin-sensitizers in cancer prevention and treatment. Insulin-sensitizers improve the metabolic and hormonal profile in PCOS patients and may also act as anticancer agents, especially in cancers associated with hyperinsulinemia and oestrogen dependent cancers. Several lines of evidence support ...
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Evidence-Based Answer Metformin, pioglitazone (Actos), and rosiglitazone (Avandia) can be used to improve menstrual cycling in women with PCOS. (Strength of Recommendation [SOR]: A, based on a meta-analysis.) However, metformin is much less effective than oral contraceptives (OCs). (SOR: A, based on a meta-analysis of randomized controlled trials [RCTs].) A Cochrane review of 44 RCTs (N = 3,992...
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ژورنال
عنوان ژورنال: International Congress Series
سال: 2005
ISSN: 0531-5131
DOI: 10.1016/j.ics.2004.12.041